CACNA2D2 Polyclonal Antibody

Background:
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cell Biology, Neuroscience, Signal Transduction

Synonyms:
Alpha 2 delta calcium channel subunit, CA2D2, CACNA2D, Cacna2d2, Calcium channel, voltage-dependent, alpha 2/delta subunit 2, Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26, Calcium voltage gated channel auxiliary subunit alpha2delta 2, Gene 26, KIAA0558, LUAC11.1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2

Immunogen: Synthetic peptide of human CACNA2D2

Swissprot: Q9NY47
Gene Accession: NP001167522

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.