GRB14 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP70238
Background:
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Other Names:
GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein
Antigen Type: synthetic peptide
Antigen Type: GRB14
Gene ID: 2888
Primary Accession: Q14449
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Other Names:
GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein
Antigen Type: synthetic peptide
Antigen Type: GRB14
Gene ID: 2888
Primary Accession: Q14449
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