CAD (phospho-Ser1859) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II)| aspartate transcarbamoylase| and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade| which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Area: Cancer, Cell biology, Epigenetics and nuclear signaling, Metabolism

Synonyms: CAD , Ser1859 , CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase, EC 6.3.5.5, Aspartate carbamoyltransferase, EC 2.1.3.2, Dihydroorotase, EC 3.5.2.3,

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year