Cadherin-N/N-Cadherin polyclonal, anti-human

Quantity: 200 µl

Description:
N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Isotype: Rabbit Polyclonal IgG

Immunogen:
Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Form: Affinity purified, in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Reactivity: human

Applications: IHC-P

Working DIlution: IHC: 1:25

Positive Control:
Adrenal Gland, Liver, Pancreas

Storage: 2-8C for immediate use. -20C for long term.