Calcineurin A polyclonal, anti-human

Quantity: 100 µg

Background:
Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.

Description:
Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA) detection. Tested with WB in Human.

Synonyms:
Alpha isoform formerly PPP2B antibody, Calcineurin A alpha antibody, Calcineurin A1 antibody, CalcineurinA antibody, Calmodulin dependent calcineurin A subunit alpha isoform antibody, Calmodulin-dependent calcineurin A subunit alpha isoform antibody, CALN antibody, CALNA 1 antibody, CALNA antibody, CALNA1 antibody, CAM PRP catalytic subunit antibody, CAM-PRP catalytic subunit antibody, CCN 1 antibody, CCN1 antibody, CNA 1 antibody, CNA alpha antibody, CNA antibody, CNA1 antibody, FLJ26613 antibody, MGC52248 antibody, PP2BA_HUMAN antibody, PPP2B antibody, PPP3CA antibody, Protein phosphatase 2B catalytic subunit antibody, Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody, Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody, Protein phosphatase 3 catalytic subunit alpha isozyme antibody, Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Calcineurin A (488-521aa DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ), different from the related mouse and rat sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.