Calcineurin A polyclonal, anti-human, mouse, rat

Background:
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-Aα, PP2B-Aβ and PP2B-Aγ. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2.

Alternative Name:
PPP3CA, Alpha isoform formerly PPP2B, Calcineurin A alpha, Calcineurin A1, CalcineurinA, Calmodulin dependent calcineurin A subunit alpha isoform, Calmodulin-dependent calcineurin A subunit alpha isoform, CALN, CALNA 1, CALNA, CALNA1, CAM PRP catalytic subunit, CAM-PRP catalytic subunit, CCN 1, CCN1, CNA 1, CNA alpha, CNA, CNA1, PP2BA, PPP2B, Ppp3ca, Protein phosphatase 2B catalytic subunit, Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform, Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA, Protein phosphatase 3 catalytic subunit alpha isozyme, Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,

Application Dilution:
WB:1:500-1:1,000
FC:1:50-1:100

Specificity: Calcineurin A polyclonal antibody detects endogenous levels of Calcineurin A protein.

Immunogen:
recombinant protein

MW: 59 kD

Swiss-Prot: Q08209(Human) P63328(Mouse) P63329(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.