Calcineurin A polyclonal, anti-human, mouse, rat, rabbit, hamster, bovine antibody
€295.00
In stock
SKU
AC-ABV10056-100
Catalog Number: AC-ABV10056-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IP
Datasheet
Request Information
Background:
Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant dr µgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
Other Names:
PPP3CA, CCN1, CNA1, CALN, CALNA, CALNA1, PPP2B
Primary Accession: P16298
Gene Name: PPP3CB
Gene ID: 5532
Concentration (mg/ml): 0.2 mg/ml
Calcineurin is a calcium/calmodulin-dependent serine/threonine protein phosphatase. The active enzyme is a heterodimer consisting of a catalytic A subunit of 61 kDa and a myristylated regulatory B subunit of 19 kDa that binds calcium. The catalytic A subunit consists of an amino terminal catalytic domain, followed by calmodulin and B subunit binding sites, and a caboxyl-terminal autoinhibitory domain. Calnineurin is the target of immunosuppressant dr µgs such as cyclosporin A and FK506. Calcineurin controls the translocation of nuclear factors of activated T cells (NFAT), a family of transcriptional activators that control the expression of cytokine genes essential to immune response, from the cytosol into the nucleus of activated T cells. Calcineurin has been proposed to play an important role in mediating calcium-activated cell death.
Other Names:
PPP3CA, CCN1, CNA1, CALN, CALNA, CALNA1, PPP2B
Primary Accession: P16298
Gene Name: PPP3CB
Gene ID: 5532
Concentration (mg/ml): 0.2 mg/ml
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