Caldesmon (Smooth) (clone hHCD), anti-human, mouse
€455.00
In stock
SKU
AC-ABO10404
Catalog Number: AC-ABO10404
Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-P
Datasheet
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Size: 100 µg
Isotype: Mouse IgG
Applications: WB, IHC-P
Datasheet
Request Information
Description: Mouse IgG monoclonal antibody for Caldesmon (smooth), caldesmon 1 (CALD1) detection. Tested with WB, IHC-P in Human;mouse;rabbit. No cross reactivity with other proteins.Protein Name: Caldesmon
Protein Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. .
Other Names: Non-muscle caldesmon, CDM, L-caldesmon, Cald1
Clone Name(s):
hHCD
Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, myofibril . On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). .
Tissue Specificity: High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low- molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Gene ID: 25687
Immunogen: Human uterus smooth muscle extract.
Calculated MW: 60584
Purification: Ascites
Format: Liquid
Contents: Each vial contains 50% glycerol, 1.2% Sodium acetate, 1% BSA, 0.02% NaN3.
Storage: At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.
Protein Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. .
Other Names: Non-muscle caldesmon, CDM, L-caldesmon, Cald1
Clone Name(s):
hHCD
Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, myofibril . On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). .
Tissue Specificity: High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low- molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Gene ID: 25687
Immunogen: Human uterus smooth muscle extract.
Calculated MW: 60584
Purification: Ascites
Format: Liquid
Contents: Each vial contains 50% glycerol, 1.2% Sodium acetate, 1% BSA, 0.02% NaN3.
Storage: At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.
| Is Featured? | No |
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