Calmodulin polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Calmodulin, calcium-modulated protein, is a calcium-binding protein expressed in all eukaryotic cells. It can bind to and regulate a number of different protein targets, thereby affecting many different cellular functions. Calmodulin mediates processes such as inflammation, metabolism, apoptosis, smooth muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that Calmodulin binds are unable to bind calcium themselves, and as such use Calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. Calmodulin undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. Calmodulin can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which has potential to modulate its actions. Calmodulin can also bind to edema factor toxin from the anthrax bacteria. Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Three calmodulin genes(CALM1, CALM2, and CALM3) map to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3, respectively.

Description:
Rabbit IgG polyclonal antibody for Calmodulin (CALM1&CALM2&CALM3) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
CALM 1 antibody, CALM 2 antibody, CALM 3 antibody, CALM antibody, CALM_HUMAN antibody, CALM1 antibody, CALM2 antibody, CALM3 antibody, CALML2 antibody, calmodulin 1(phosphorylase kinase, delta) antibody, Calmodulin 1 antibody, Calmodulin 2(phosphorylase kinase, delta) antibody, Calmodulin 3(phosphorylase kinase, delta) antibody, Calmodulin antibody, Calmodulin1 antibody, CAM 1 antibody, CAM 2 antibody, CAM 3 antibody, CaM antibody, CAM I antibody, CAM1 antibody, CAM2 antibody, CAM3 antibody, CAMB antibody, CAMC antibody, CAMI antibody, CAMII antibody, CAMIII antibody, CPVT4 antibody, DD132 antibody, FLJ99410 antibody, LP7057 protein antibody, PHKD antibody, PHKD antibody, PHKD2 antibody, PHKD3 antibody, Phosphorylase kinase delta antibody, Phosphorylase kinase delta subunit antibody, phosphorylase kinase, delta subunit antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Calmodulin(119-136aa DEEVDEMIREADIDGDGQ), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.