Calpain 11 rabbit polyclonal, anti-human, mouse, rat

Backgroud: Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,

Synonyms: CAPN11, Calpain-11, Calcium-activated neutral proteinase 11, CANP 11

Gene Name: CAPN11

Gene ID: 11131

SwissProt ID: Q9UMQ6

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.