Calpain 2 polyclonal, anti-human, mouse, rat

Background:
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, is thought to play a role in cytoskeletal reorganization and muscle protein degradation. Calpain exists as a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.

Alternative Name:
CANP 2, M-calpain, CAPN2, CANPL2, Calcium activated neutral proteinase 2, Calcium activated neutral proteinase, Calcium-activated neutral protease 2, catalytic subunit, Calcium-activated neutral proteinase 2, CALP80, Calpain 2 (m/II) large subunit, Calpain 2 catalytic subunit, Calpain 2 large catalytic subunit, Calpain 2 large subunit, Calpain 2, large [catalytic] subunit, Calpain large polypeptide L2, Calpain M type, Calpain M-type, Calpain-2 catalytic subunit, Calpain-2 large subunit, Calpain2, CAN2, CANP 2, CANP L2, CANP2, CANPL 2, CANPL2, CANPml, Capa2, CAPN 2, CAPN2, FLJ39928, M calpain, M calpin, M type, M-calpain, mCANP, Millimolar calpain, Millimolar-calpain,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200

Specificity: Calpain 2 polyclonal antibody detects endogenous levels of Calpain 2 protein.

Immunogen:
recombinant protein

MW: 80 kDa

Swiss-Prot: P17655(Human) O08529(Mouse) Q07009(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.