Calpain-6 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Peptidases

Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction

Description:
Calpains are calcium-dependent intracellular nonlysosomal proteases that are believed to participate in signal transduction. In vertebrates, five different calpains have so far been identified, of which three ( μ-, m-, and μ/m-calpain) are ubiquitously expressed while the other two, nCL-1 (p94) and nCL-2, exhibit a restricted tissue distribution. Calpain-6 possesses most of the residues conserved in calpain family members but the C-terminal region lacks any homology to the calmodulin-like domain of other vertebrate calpains. Calpain-6 lacks critical active site residues and is not proteolytically active. Calpain-6 is highly expressed in the placenta sample.

Alternate Names: Calpain-6, Calpamodulin, CalpM, Calpain-like protease X-linked, CAPN6, CALPM, CANPX

Application Notes: E: 1:2,000-1:8,000; WB: 1:200-1:1,000

Accession No.: Q9Y6Q1

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human calpain-6.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.