Calreticulin polyclonal, anti-human, mouse, rat antibody

Background:
Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies s µggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also s µggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.

Other Names:
CRP55, CRTC, CALR, Calregulin, cC1qR, ERp60, HACBP, RO, SSA,

Primary Accession: P27797

Gene Name: CALR (HGNC:1455)

Gene ID: 811

Concentration (mg/ml): 0.2 mg/ml