Calreticulin Rabbit pAb

Background:
Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation . 

Cellular localization: Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

Specificity: Human

Alternative Names:
CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA

Immunogen: Recombinant Protein

Isotype: Rabbit Polyclonal IgG

Concentration: 1mg/ml

Recommended dilutions: WB 1:500-1,000

Observed band: 55kDa

GeneID: 811

Swiss-Prot No.: P27797

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Store at -20°C. Avoid repeated freeze-thaw cycles.

NOTE: For Research Use Only