Calsequestrin 1 polyclonal, anti-human, mouse, rat

Background:
Calsequestrin (CS, also known as CSQ) is the major calcium-binding protein of cardiac and skeletal muscle whose function is to sequester calcium in the lumen of the sarcoplasmic reticulum (SR). In mammals, there are two forms of this protein, calsequestrin 1 and calsequestrin 2, which encode fast-twitch skeletal muscle and cardiac calsequestrin, respectively. Calsequestrin 1, also known as Calmitin, is located in the terminal cisternae luminal spaces of the SR of fast skeletal muscle cells. Calsequestrin 2 is present in terminal cisternae luminal spaces of the SR of both cardiac and slow skeletal muscle cells. In addition, calsequestrin regulates the ryanodine receptor signaling (RyR) through Triadin and Junctin.

Alternative Name:
CASQ1, CASQ, Calmitin, Calmitine, Calsequestrin 1 (fast twitch, skeletal muscle), Calsequestrin, Calsequestrin, cell, Calsequestrin, skeletal muscle isoform, Calsequestrin-1, CASQ, Casq1, CASQ1, PDIB1, skeletal muscle isoform,

Application Dilution:
WB:1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Calsequestrin 1 polyclonal antibody detects endogenous levels of Calsequestrin 1 protein.

Immunogen:
Recombinant protein

MW: 45 kDa

Swiss-Prot: P31415(Human) O09165(Mouse) P19633(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.