CaMKII delta CAMK2D monoclonal, anti-human, mouse, rat

Description: Anti-CaMKII delta CAMK2D Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca (2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca (2+) influx into the myocyte, Ca (2+) release from the sarcoplasmic reticulum (SR), SR Ca (2+) uptake and Na (+) and K (+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca (2+) release via direct phosphorylation of RYR2 Ca (2+) channel on 'Ser- 2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca (2+) influx to myocytes by binding and phosphorylating the L-type Ca (2+) channel subunit beta-2 CACNB2. In addition to Ca (2+) channels, can target and regulate the cardiac sarcolemmal Na (+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca (2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca (2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor- coupling factor..

Other Names: Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, 2.7.11.17, CAMK2D, CAMKD

Clone Name(s):
Clone: ABBF-3

Subcellular Localization: Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side. Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side.

Tissue Specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle..

Gene ID: 817

Immunogen: A synthesized peptide derived from human CaMKII delta

Calculated MW: 56369

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.