CaMKII Substrate Peptide

Protein Family: Protein Kinases, Enzymes

Pathway and Disease: Signal Transduction, Nervous and Sensory Systems, Glycan Biosynthesis and Metabolism

Alternate Names: Substrate: Glycogen synthase; GYS1; GYS; Enzyme: Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2A; CAMKA; KIAA0968

Accession No.: P13834, Q9UQM7

Description:
This peptide is a substrate (Km = 7.5 mM) for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the residues 1-10 of the glycogen synthase containing a phosphorylation site at Ser-7 within the R-X-X-S/T consensus site and is amidated at the C-terminus end. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Phosphorylation of the substrate is calcium and calmodulin dependent.

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 1045.1 g/mol

Sequence:
Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ser-Ser-NH2 or PLSRTLSVSS-NH2

Composition:
C44H80N18O15

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.