CaMKIIα/δ (phospho-T286) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4773
Background:
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIIα is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
Alternative Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968, CaMK2-a, CaMK2a, CaMK-2a, Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, CAMK2D, CAMKD, CaMK2-δ, CaMK2δ, CaMK-2δ,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-CaMKIIα/δ (T286) polyclonal antibody detects endogenous levels of CaMKIIα/δprotein only when phosphorylated at Thr286.
Immunogen:
Synthetic phosphopeptide derived from human CaMKIIα around the phosphorylation site of Threonine 286.
MW: ~ 54 kDa
Swis Prot.: Q9UQM7/Q13557
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIIα is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
Alternative Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968, CaMK2-a, CaMK2a, CaMK-2a, Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, CAMK2D, CAMKD, CaMK2-δ, CaMK2δ, CaMK-2δ,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-CaMKIIα/δ (T286) polyclonal antibody detects endogenous levels of CaMKIIα/δprotein only when phosphorylated at Thr286.
Immunogen:
Synthetic phosphopeptide derived from human CaMKIIα around the phosphorylation site of Threonine 286.
MW: ~ 54 kDa
Swis Prot.: Q9UQM7/Q13557
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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