CaMKK polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CAMKK1, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene. The CAMKK1 gene is mapped to chromosome 17. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity. Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2. Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation.

Description:
Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Ca2+/calmodulin-dependent protein kinase kinase alpha antibody, Calcium/calmodulin dependent protein kinase kinase antibody, Calcium/calmodulin dependent protein kinase kinase 1 alpha antibody, Calcium/calmodulin dependent protein kinase kinase 1 antibody, Calcium/calmodulin dependent protein kinase kinase alpha antibody, Calcium/calmodulin-dependent protein kinase kinase 1 antibody, Calcium/calmodulin-dependent protein kinase kinase alpha antibody, CaM kinase kinase alpha antibody, CaM-kinase IV kinase antibody, CaM-kinase kinase 1 antibody, CaM-kinase kinase alpha antibody, CaM-KK 1 antibody, CaM-KK alpha antibody, CaMKK 1 antibody, CaMKK alpha antibody, CAMKK alpha protein antibody, CaMKK antibody, CAMKK1 antibody, CAMKKA antibody, DKFZp761M0423 antibody, KKCC1_HUMAN antibody, MGC34095 antibody, OTTMUSP00000006419 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK(10-31aa QDPRAELVDRVAAINVAHLEEA), different from the related human sequence by three amino acids, and from the related rat sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.