CAMKK2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, is an enzyme that in humans is encoded by the CAMKK2 gene. The product of this gene belongs to the serine/threonine-specific protein kinase family, and to the Ca++/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus. It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, through reduction in downstream signalling pathways and mu opioid receptor downregulation. Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss.

Description:
Rabbit IgG polyclonal antibody for Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
Calcium/calmodulin dependent protein kinase beta antibody, Calcium/calmodulin dependent protein kinase kinase 2 antibody, Calcium/calmodulin dependent protein kinase kinase 2 beta antibody, Calcium/calmodulin dependent protein kinase kinase beta antibody, Calcium/calmodulin-dependent protein kinase kinase 2 antibody, Calcium/calmodulin-dependent protein kinase kinase beta antibody, CaM kinase kinase beta antibody, CaM KK beta antibody, CaM-kinase kinase 2 antibody, CaM-kinase kinase beta antibody, CaM-KK 2 antibody, CaM-KK beta antibody, CAMKK 2 antibody, CAMKK antibody, CaMKK beta antibody, CAMKK beta protein antibody, Camkk2 antibody, CAMKKB antibody, KKCC2_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human CAMKK2(180-194aa KLAYNENDNTYYAMK), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.