CAPN10 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7347a
Background:
CAPN10 is ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. This protein is heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. The protein is similar in organization to calpains 5 and 6.
Other Names:
Calpain-10, 3422-, Calcium-activated neutral proteinase 10, CANP 10, CAPN10, KIAA1845
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7347a was selected from the N-term region of human CAPN10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CAPN10
Gene ID: 11132
Primary Accession: Q9HC96
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CAPN10 is ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. This protein is heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. The protein is similar in organization to calpains 5 and 6.
Other Names:
Calpain-10, 3422-, Calcium-activated neutral proteinase 10, CANP 10, CAPN10, KIAA1845
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7347a was selected from the N-term region of human CAPN10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CAPN10
Gene ID: 11132
Primary Accession: Q9HC96
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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