CAPN3 Polyclonal Antibody

Background:
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Research Area: Cell Biology, Signal transduction

Synonyms:
Calcium-activated neutral proteinase 3, calpain 3, (p94), Calpain L3, Calpain large polypeptide L3 , Calpain p94, calpain p94, large [catalytic] subunit, calpain, large polypeptide L3, Calpain-3, CAN3, CANP 3, CANP3, CANPL3, CAPN3, LGMD 2A, LGMD2, LGMD2A, Lp82, Lp85, MGC10767, MGC11121, MGC14344, MGC4403, Muscle-specific calcium-activated neutral protease 3, muscle-specific calcium-activated neutral protease 3 large subunit, nCL-1, New calpain 1, p94

Immunogen: Fusion protein of human CAPN3

Swissprot: P20807
Gene Accession: BC003521

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.4 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.