CAPN3 Polyclonal Antibody

Background:
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.

Research Area: Cell Biology, Signal transduction

Synonyms:
CAPN3, CANP3, CANPL3, LGMD2, LGMD2A, nCL-1, p94, calpain-3

Immunogen: Recombinant fusion protein of human CAPN3 (NP_775111.1).

Swissprot: P20807
Gene ID: 825

Calculated MW: 18 kDa/35 kDa/84 kDa/93 kDa/94 kDa
Observed MW: 114 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.