Carcinoembryonic Antigen (CEA) polyclonal, anti-human

Quantity: 100 µl

Background:
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced in gastrointestinal tissue during fetal development, but the production of CEA stops before birth. CEA is a glycosyl phosphatidyl inositol (GPI) cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.

Synonyms:
CEA

Isotype: Rabbit Polyclonal

Immunogen:
Human carcinoembyonic antigen (CEA)

Form: Serum containing 0.1% sodium azide

Specificity:
The antiserum reacts with a large variety of tumors with oncofetal characteristics; the antigen may also be detected in normal epithelia and tissue of non-neoplastic state.

Reactivity: human

Applications: Immunohistochemistry on frozen and paraffin sections, Immunofluorescence

Working DIlution: 1:50 to 1:125 using PAP; 1:50 to 1:100 using FITC

Positive Control:
Bouin-fixed paraffin sections of human colon carcinoma

Storage: 2-8C for immediate use, or at -20C (aliquot)