CARD11 (Phospho-Ser652) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family| a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family| which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10| a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells| this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Research Area: Cancer, Cell biology, Epigenetics and nuclear signaling, Immunology, Signal transduction

Synonyms: CARD11 , Ser652, Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year