CARD11 polyclonal, anti-human

Background:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Other Names:
Caspase recruitment domain-containing protein 11, CARD-containing MAGUK protein 1, Carma 1, CARD11, CARMA1

Antigen Types:
Synthetic Peptide

Gene Name:
CARD11 {ECO:0000303|PubMed:11278692, ECO:0000312|HGNC:HGNC:16393}
Gene ID:
84433
Primary Accession: Q9BXL7
Other Accession: NP_115791;84433;108723 (mouse);