CARD11 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Synonyms:
CARD11, BENTA, BIMP3, CARMA1, IMD11, PPBL

Immunogen: Recombinant fusion protein of human CARD11 (NP_115791.3).

Swissprot: Q9BXL7
Gene ID: 84433

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.