CARD14 antibody (clone 4B3), anti-human
€435.00
In stock
SKU
AC-AT1396a
Catalog Number: AC-AT1396a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
Request Information AC-AT1396a">Request Information
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: E
Request Information AC-AT1396a">Request Information
Background:
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.
Other Names:
Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2, CARD14, CARMA2
Antigen Type:
Recombinant Protein
Gene Name: CARD14
Gene ID: 79092
NCBI Accession: NP_001244899.1;NP_077015.2;NP_438170.1
Primary Accession: Q9BXL6
Other Accession: NM_024110
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.
Other Names:
Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2, CARD14, CARMA2
Antigen Type:
Recombinant Protein
Gene Name: CARD14
Gene ID: 79092
NCBI Accession: NP_001244899.1;NP_077015.2;NP_438170.1
Primary Accession: Q9BXL6
Other Accession: NM_024110
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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