CARD15 / NOD2 (Internal) polyclonal, anti-human

Background:
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

Other Names:
Nucleotide-binding oligomerization domain-containing protein 2, Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NOD2, CARD15, IBD1

Antigen Types:
Synthetic Peptide

Gene Name:
NOD2 {ECO:0000303|PubMed:11087742, ECO:0000312|HGNC:HGNC:5331}
Gene ID:
64127
Primary Accession: Q9HC29
Other Accession: NP_071445;64127;257632 (mouse); 291912 (rat);