CARD16 Polyclonal Antibody

Background:
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.

Research Area: Cell Biology

Synonyms:
CAR16, CARD only domain-containing protein 1, CARD only protein , CARD16, Caspase recruitment domain family, member 16, Caspase recruitment domain-containing protein 16, Caspase-1 dominant-negative inhibitor pseudo-ICE , Caspase-1 inhibitor COP, COP, COP1, Pseudo interleukin 1 beta converting enzyme, Pseudo interleukin-1 beta converting enzyme, Pseudo interleukin-1beta converting enzyme , PSEUDO-ICE

Immunogen: Synthetic peptide of human CARD16

Swissprot: Q5EG05
Gene Accession: NP001017534

Calculated MW: 23 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.