Cardiotin (clone R2G), anti-human, mouse, rat, canine, feline, caprine, hamster, monkey, rabbit, xenopus, zebrafish

Background:
Cardiotin is a high molecular weight protein complex (300 kDa) loCated in the mitochondria of cardiomyocytes and skeletal muscle. The cardiotin structure exists of subunits of 60 kDa and 100 kDa, probably in a tetrameric configuRation. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to Human skeletal muscle alpha-actinin. During cardiac contractile dysfunction and myocard cell differentiation, the cardiotin distribution is affected. Compared to other structural proteins, cardiotin is one of the first to respond to insults (ischemia, fibrillation) that influence the functional status of cardiomyocytes.

Clone: R2G

Isotype: Mouse IgM

Source: R2G is a Mouse monoclonal IgM antibody derived by fusion of SP2/0-Ag14 Mouse myeloma cells, with spleen cells from a Mouse immunized with a total protein extract of Chicken gizzard.

Reactivity: canine, feline, caprine, hamster, human, monkey, mouse, rabbit, rat, xenopus, zebrafish

Specificity: R2G reacts with cardiotin, a mitochondrion-associated protein, which is present in cardiomyocytes and skeletal muscle.

Form: Each vial contains 100 ul purified monoclonal antibody in PBS containing 0.09% sodium azide.

Applications: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western blotting

Storage: Store at 4C, or in small aliquots at -20C.