CASC5 Blocking Peptide (C-Term)

Background:
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.

Other Names:
Protein CASC5, ALL1-fused gene from chromosome 15q14 protein, AF15q14, Bub-linking kinetochore protein, Blinkin, Cancer susceptibility candidate gene 5 protein, Cancer/testis antigen 29, CT29, Kinetochore-null protein 1, Protein D40/AF15q14, CASC5, KIAA1570, KNL1

Target/Specificity:
The synthetic peptide sequence is selected from aa 2324-2337 of HUMAN CASC5

Gene Name: KNL1 (HGNC:24054)

Gene ID: 57082
Primary Accession: Q8NG31
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.