Casein Kinase IIβ (phospho-S209) polyclonal, anti-human, mouse, rat

Background:
CK2 (formerly called Casein Kinase II) is a highly conserved protein kinase with more than 300 substrates regulating cell growth, cell death, and cell survival. CK2 has been implicated in the response to UV irradiation-induced DNA damage, targeting XRCC1 and BRCA1 as well as regulating p53 tumor suppressor protein functions.Furthermore, CK2 plays a key role in NF-κB activation.

Alternative Name:
Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8

Application Dilution:
WB: 1:500~1:1000

Specificity: Casein Kinase IIβ (phospho-S209) polyclonal antibody detects endogenous levels of Casein Kinase IIβ protein only when phosphorylated at Ser209.

Immunogen:
Synthetic phosphopeptide derived from human Cytokeratin 8 around the phosphorylation site of Serine 432

MW: ~ 27 kDa

Swiss-Prot: P67870

Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at 4°C short term. Aliquot and store at -21°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.