CASP10 antibody (clone 1D8), anti-human
€435.00
In stock
SKU
AC-AT1401a
Catalog Number: AC-AT1401a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: E
Request Information AC-AT1401a">Request Information
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: E
Request Information AC-AT1401a">Request Information
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Other Names:
Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Caspase-10 subunit p23/17, Caspase-10 subunit p12, CASP10, MCH4
Antigen Type:
Recombinant Protein
Gene Name: CASP10
Gene ID: 843
NCBI Accession: NP_001193453.1;NP_001193471.1;NP_001221.2;NP_116756.2;NP_116758.1;NP_116759.2
Primary Accession: Q92851
Other Accession: NM_032974
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Other Names:
Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Caspase-10 subunit p23/17, Caspase-10 subunit p12, CASP10, MCH4
Antigen Type:
Recombinant Protein
Gene Name: CASP10
Gene ID: 843
NCBI Accession: NP_001193453.1;NP_001193471.1;NP_001221.2;NP_116756.2;NP_116758.1;NP_116759.2
Primary Accession: Q92851
Other Accession: NM_032974
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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