CASP10 Polyclonal Antibody

Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
ALPS2, Apoptotic protease Mch-4, CASP 10, CASP-10, CASP10, CASPA, Caspase 10 apoptosis related cysteine peptidase, Caspase-10 subunit p12, FADD like ICE2, Fas associated death domain protein, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE 2, FLICE2, ICE like apoptotic protease 4, ICE-like apoptotic protease 4, Interleukin 1B converting enzyme 2, MCH 4

Immunogen: Recombinant protein of human CASP10

Swissprot: Q92851
Gene Accession: BC042844

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-22184/sc-6184/sc-6186/sc-6185/sc-7955