CASP12 Polyclonal Antibody

Background:
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Research Area: Cancer, Cell Biology, Metabolism, Neuroscience

Synonyms:
CASP 12, CASP-12, Casp12, CASP12P1, caspase 12 (gene/pseudogene), caspase 12 pseudogene 1, CASPC, Inactive caspase-12, OTTHUMP00000207032

Immunogen: Synthetic peptide of human CASP12

Swissprot: Q6UXS9
Gene Accession: NP_001177945

Calculated MW: 55 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-12395/sc-12396/sc-5627