CASP14 antibody (clone 4C9), anti-human
€435.00
In stock
SKU
AC-AT1403a
Catalog Number: AC-AT1403a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT1403a">Request Information
Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Other Names:
Caspase-14, CASP-14, 3422-, Caspase-14 subunit p19, Caspase-14 subunit p10, CASP14
Antigen Type:
Recombinant Protein
Gene Name: CASP14
Gene ID: 23581
NCBI Accession: NP_036246.1
Primary Accession: P31944
Other Accession: NM_012114
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Other Names:
Caspase-14, CASP-14, 3422-, Caspase-14 subunit p19, Caspase-14 subunit p10, CASP14
Antigen Type:
Recombinant Protein
Gene Name: CASP14
Gene ID: 23581
NCBI Accession: NP_036246.1
Primary Accession: P31944
Other Accession: NM_012114
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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