CASP2 Polyclonal Antibody

Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
CASP 2, CASP-2, Casp2, CASP2, Caspase 2, Caspase 2 apoptosis related cysteine peptidase, Caspase-2 subunit p12, Caspase2, ICH 1, ICH 1 protease, ICH 1L, ICH1, ICH1 protease, ICH1L, NEDD-2, NEDD2, Neural precursor cell expressed developmentally down-regulated protein 2, PPP1R57, Protease ICH-1, Protein phosphatase 1 regulatory subunit 57

Immunogen: Recombinant protein of human CASP2

Swissprot: P42575
Gene Accession: BC002427

Calculated MW: 51 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:1000-1:5000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-22169/sc-623/sc-626/sc-625/sc-8985/sc-15379