CASP3 polyclonal, anti-human, mouse

Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Synonyms: CPP32, CPP32B, SCA-1, SREBP cleavage activity 1, Cysteine protease CPP32

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human CASP3

Gene Symbol: CASP3

Gene ID: 836

Swiss prot: P42574

Calculated MW: 31kDa

Recommended dilution:
WB 1:500-2000, IHC 1:80,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.