CASP4 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6723a
Background:
CASP4 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, it induces cell apoptosis.
Other Names:
Caspase-4, CASP-4, ICE(rel)-II, Protease ICH-2, Protease TX, Caspase-4 subunit 1, Caspase-4 subunit 2, CASP4, ICH2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6723a was selected from the N-term region of human CASP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CASP4 {ECO:0000303|PubMed:15123740, ECO:0000312|HGNC:HGNC:1505}
Gene ID: 837
Primary Accession: P49662
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CASP4 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, it induces cell apoptosis.
Other Names:
Caspase-4, CASP-4, ICE(rel)-II, Protease ICH-2, Protease TX, Caspase-4 subunit 1, Caspase-4 subunit 2, CASP4, ICH2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6723a was selected from the N-term region of human CASP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CASP4 {ECO:0000303|PubMed:15123740, ECO:0000312|HGNC:HGNC:1505}
Gene ID: 837
Primary Accession: P49662
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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