CASP4 polyclonal, anti-human

Background:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Other Names:
Caspase-4, CASP-4, 3.4.22.57, ICE(rel)-II, Protease ICH-2, Protease TX, Caspase-4 subunit 1, Caspase-4 subunit 2, CASP4, ICH2

Antigen Types:
Synthetic Peptide

Gene Name:
CASP4 {ECO:0000303|PubMed:15123740, ECO:0000312|HGNC:HGNC:1505}
Gene ID:
837
Primary Accession: P49662
Other Accession: NP_150649;837;