CASP4 polyclonal, anti-human

Background:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Synonyms: TX, Mih1, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II

Cellular Location: Cytoplasm Membrane

Immunogen:
A synthetic peptide of human CASP4

Gene Symbol: CASP4

Gene ID: 837

Swiss prot: P49662

Calculated MW: 43/37/13/30/18kDa

Recommended dilution:
IHC 1:30-150

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.