CASP4 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

Synonyms: CASP-11, CASP-4, Casp11, Caspl, ich-3

Cellular Location: Endoplasmic reticulum Mitochondrion Cytosol secreted

Immunogen:
Recombinant protein of mouse CASP4

Gene Symbol: CASP4

Gene ID: 12363

Swiss prot: P49662

Calculated MW: 43kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.