CASP5 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP10944b
Catalog Number: AC-AP10944b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18988
Applications: WB, FC, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18988
Applications: WB, FC, IHC-P
Datasheet
Request Information
Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Other Names:
Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3
Target/Specificity:
This CASP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human CASP5.
Antigen Region:
162-191
Antigen Type: Synthetic Peptide
Gene Name: CASP5 {ECO:0000303|PubMed:16893518, ECO:0000312|HGNC:HGNC:1506}
Gene ID: 838
Primary Accession: P51878
NCBI Accession: NP_001129581.1;NP_001129582.1;NP_001129584.1;NP_004338.3
Other Accession: NP_001129582.1;NP_001129584.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Other Names:
Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3
Target/Specificity:
This CASP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human CASP5.
Antigen Region:
162-191
Antigen Type: Synthetic Peptide
Gene Name: CASP5 {ECO:0000303|PubMed:16893518, ECO:0000312|HGNC:HGNC:1506}
Gene ID: 838
Primary Accession: P51878
NCBI Accession: NP_001129581.1;NP_001129582.1;NP_001129584.1;NP_004338.3
Other Accession: NP_001129582.1;NP_001129584.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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