CASP8 polyclonal, anti-human

Background:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli.

Synonyms: ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human CASP8

Gene Symbol: CASP8

Gene ID: 841

Swiss prot: Q14790

Calculated MW: 55kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.