CASP8 Polyclonal Antibody

Background:
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3. It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. Caspase 8 Monoclonal Antibody can recognize pro- and cleaved-caspase 8.

Research Area: Cancer, Cell Biology, Metabolism

Synonyms:
ALPS2B, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, Apoptotic cysteine protease, Apoptotic protease Mch-5, Apoptotic protease Mch5, CAP4, CASP-8, CASP8, CASP8, Caspase 8, Caspase 8 apoptosis related cysteine peptidase, Caspase-8 subunit p10, CED 3, FADD Like ICE, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, FLJ17672, ICE-like apoptotic protease 5, MACH alpha 1/2/3 protein, MACH, MACH beta 1/2/3/4 protein, MCH5, MGC78473, MORT1 associated ced 3 homolog, MORT1-associated CED-3 homolog, OTTHUMP00000163717, OTTHUMP00000163720, OTTHUMP00000163724, OTTHUMP00000163725, OTTHUMP00000165062, OTTHUMP00000165063, OTTHUMP00000165064, OTTHUMP00000206552, OTTHUMP00000206582

Immunogen: Synthetic peptide of human CASP8

Swissprot: Q14790
Gene Accession: NP203519

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.