CASP8AP2 Polyclonal Antibody

Background:
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.

Research Area: Cancer, Cell Biology

Synonyms:
CASP8AP2, CED-4, FLASH, RIP25

Immunogen: Recombinant fusion protein of human CASP8AP2 (NP_036247.1).

Swissprot: Q9UKL3
Gene ID: 9994

Calculated MW: 222 kDa
Observed MW: 215 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.