Caspase-1 (p10) (clone Casper-2), anti-mouse
€274.00
In stock
SKU
ARP-23-B0044
Catalog Number: 23-B0044
Size: 25 µg
Isotype: Mouse IgG2a
Size: 25 µg
Isotype: Mouse IgG2a
Decription:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE
Clone: Casper-2
Isotype: Mouse IgG2a
Immunogen: Recombinant mouse caspase-1.
Reactivity: mouse
Specificity: Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot (see online protocol): (1?g/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE
Clone: Casper-2
Isotype: Mouse IgG2a
Immunogen: Recombinant mouse caspase-1.
Reactivity: mouse
Specificity: Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.
Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.
Applications: Western Blot (see online protocol): (1?g/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation)
Working Dilution: Optimal conditions must be determined individually for each application.
Concentration: 1mg/ml
Storage: 2-8C immediate use, or -20C (aliquote)
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