Caspase-1 (p10) (clone Casper-2) biotin, anti-mouse

Decription:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE

Clone: Casper-2

Isotype: Mouse IgG2a

Immunogen: Recombinant mouse caspase-1.

Reactivity: mouse

Specificity: Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.

Form: Biotin conjugate, in PBS containing 0.02% sodium azide.

Applications: Western Blot: (1?g/ml) (no need to precipitate the cell supernatant for the detection of caspase-1 (mouse) upon inflammasome activation)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C