Caspase-1 (p20) (clone Bally-1), anti-human

Decription:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

Synonyms: Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE

Clone: Bally-1

Isotype: Mouse IgG1

Immunogen: Recombinant human caspase-1.

Reactivity: human

Specificity: Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications: Western Blot: (1?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)